The Peroxisome Proliferator-Activated Receptor (PPAR) Resource

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that control many cellular and metabolic processes. These proteins are ligand-activated transcription factors and three isotypes called PPARa , PPARb/d and PPARg have been identified in lower vertebrates and mammals. They display differential tissue distribution and each of the three subtypes fulfills specific functions; however, all three PPARs affect energy homoeostasis and inflammatory responses. In addition, their activity can be modulated by drugs such as the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Thus, understanding the biology and identifying small molecule modulators of the PPARs is an active area of research and may impact chronic diseases such as diabetes, obesity, heart disease and atherosclerosis. The PPAR Resource Page (http://ppar.cas.psu.edu) is a website devoting to keeping scientists up-to-date with the latest research on these proteins and provides links to a variety of public databases.

The site was launched in 1998 to disseminate information about PPAR including cDNA sequences, protein alignments, DNA response elements (PPREs), and sources of cDNAs, proteins and antibodies. Recent additions include bioinformatics support such as gene expression microarray and pathway analysis links. As part of the Nuclear Receptor Resource (NRR, http://nrr.georgetown.edu/NRR/nrrhome.htm) some tools are shared with other constituents of this larger project. These include electronic publication, and a listing of scientists interested in the steroid and thyroid hormone superfamily. Receiving greater than 300 unique visits per week, the PPAR resource page has become an important tool for researchers of this important NR.

As indicated by the links to your left, the PPARR provides a variety of information on PPARs as well as more general information shared with other sites. Please feel free to submit such items via e-mail using the link below. Additional material (descriptions of new response elements, suggestions for new links, etc.) is also very welcome, and may be submitted by e-mail.