| Name | NCOA3 |
|---|---|
| Description | nuclear receptor coactivator 3 |
| Owner | Public |
| URN | urn:agi-llid:8202 |
| Connectivity | 59 |
| Notes | The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. |
| Hugo ID | 7670 |
| Microarray ID | 1388178_at |
|---|---|
| A_43_P15736 | |
| 1422737_at | |
| af000581_s_at | |
| 104180_at | |
| 1420554_a_at | |
| A_51_P454207 | |
| A_51_P455946 | |
| A_51_P499160 | |
| A_51_P499169 | |
| 209061_at | |
| 209060_x_at | |
| 33381_at | |
| 209062_x_at | |
| 211352_s_at | |
| 207700_s_at | |
| 1562439_at | |
| AA156882_at | |
| N56493_at | |
| W46488_at | |
| aa150333_at | |
| A_14_P132019 | |
| A_14_P115183 | |
| A_14_P135867 | |
| A_14_P140002 | |
| A_23_P313560 | |
| A_23_P313568 | |
| A_23_P120442 | |
| H158 | |
| OH0241 |
| Chromosome position | 2 H2-H4 |
|---|---|
| 20q12 | |
| 3q42 |
| GO ID | 0006350 |
|---|---|
| 0006355 | |
| 0045449 | |
| 0003713 | |
| 0004402 | |
| 0004871 | |
| 0005515 | |
| 0005634 | |
| 0007165 | |
| 0008415 | |
| 0016740 | |
| 0030521 | |
| 0030528 | |
| 0045893 | |
| 0046966 | |
| 0050681 |
| Alias | nuclear receptor coactivator 3 |
|---|---|
| Src3 | |
| TNRC14 | |
| TRAM-1 | |
| nuclear receptor coactivator AIB1 | |
| nuclear receptor coactivator III | |
| RAC3/SRC-3 | |
| SRC-3/RAC3 | |
| CTG26 | |
| Amplified in breast cancer I | |
| TRAM I | |
| p/CIP | |
| TNRC16 | |
| similar to nuclear receptor coactivator AIB1 | |
| similar to nuclear receptor coactivator AIB I | |
| ACTR | |
| AIB I | |
| CBP-interacting protein | |
| pCIP | |
| receptor-associated coactivator 3 | |
| receptor-associated coactivator III | |
| steroid receptor coactivator protein 3 | |
| steroid receptor coactivator protein III | |
| N-CoA3 | |
| CAGH16s | |
| TNRC14s | |
| TNRC16s | |
| SRC-3/AIB1 | |
| steroid hormone receptor coactivator (SRC) 3 | |
| nuclear receptor coactivator (N-CoA) 3 | |
| nuclear receptor coactivator AIB I | |
| AIB1 | |
| Amplified in breast cancer-1 | |
| CAGH16 | |
| NCOA3 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 11555636 |
|---|---|
| 11279242 | |
| 15572661 | |
| 9267036 | |
| 9346901 |
| LocusLink ID | 8202 |
|---|---|
| 84584 | |
| 17979 | |
| 296375 |
| FunctionalClass | acyltransferase |
|---|---|
| androgen receptor binding | |
| histone acetyltransferase | |
| protein binding | |
| signal transducer | |
| thyroid hormone receptor binding | |
| transcription coactivator | |
| transcription regulator | |
| transferase |
| RGD ID | 620109 |
|---|
| Hugo Symbol | NCOA3 |
|---|
| Unigene ID | Hs.382168 |
|---|---|
| Rn.20691 | |
| Mm.1011 |
| GO Cellular Component | nucleus |
|---|
| Cell Localization | Nucleus |
|---|
| Pathway | IL4-FCER2 |
|---|---|
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| PPARbeta | |
| LXR | |
| RXR | |
| ERbeta | |
| ERalpha | |
| LRH-1 | |
| NOR1 | |
| HNF4a | |
| TR | |
| NR common regulators |
| GO Biological Process | signal transduction |
|---|---|
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| androgen receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent |
| Group | Transcription factors |
|---|
| EC Number | 2.3.1.48 |
|---|
| State | isoform B |
|---|---|
| isoform A |
| State Description | Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a. |
|---|---|
| Transcript Variant: This variant (1) encodes the longer isoform (a). |
| MGI ID | 1276535 |
|---|
| Swiss-Prot Accession | Q9Y6Q9 |
|---|
| OMIM ID | 601937 |
|---|
| Source | Curated |
|---|