Protein : SMAD4
Name SMAD4
Description SMAD, mothers against DPP homolog 4 (Drosophila)
Owner Public
URN urn:agi-llid:4089
Connectivity 183
Notes SUMMARY: transduces signal from TGF-beta; deletion of human homolog gene is associated with pancreatic carcinomas [RGD]
Hugo ID 6770
Microarray ID 1367910_at
1386984_at
rc_ai008639_at
rc_ai235646_at
A_43_P12002
1422485_at
98546_at
u79748_s_at
A_51_P444740
U44378
202526_at
36953_at
58962_at
74813_at
202527_s_at
1565702_at
1565703_at
509_at
510_g_at
U44378_at
rc_f10678_s_at
A_23_P27346
A_14_P109814
A_14_P106230
A_14_P134632
CA251
OH8309
OR2476
RA0371
NM_019275
166567_f_at
128980_f_at
1422486_a_at
1422487_at
128949_at
160440_at
166540_at
aa542171_at
Msa.3313.0_at
NM_008540
A_65_P12257
L0204C01-3
RC_R56432_at
I_960581
GenBank ID AB010954
AF056002
BAA83092
NC_005117
NM_019275
NP_062148
NW_047516
O70437
AAA91041
AAC03051
AAH02379
AB043547
AF045447
BAB40977
BC002379
BX647129
NC_000018
NM_005359
NP_005350
NT_010966
NT_086889
Q13485
U44378
12836260
40388487
1163234
13959561
NT_082383
NW_043157
40388488
28302270
28302271
1724090
1724091
13959560
29823167
34147555
4885457
51474642
13603413
13603414
2865655
2865657
33876626
12803151
34366157
1163233
34932546
9506874
9506875
5706363
5706364
3025891
3025892
13959528
51771045
31543223
31543224
12836259
AAB57905
AAH46584
AAM74472
AAR85497
AK004804
AK170255
AY119788
AY493561
BAB23576
BC046584
NC_000084
NM_008540
NP_032566
NT_039674
P97471
U79748
AAC12781
Chromosome position 18q21.1
18 48.0 cM
GO ID GO:0005515
GO:0003677
GO:0007184
GO:0006355
GO:0006357
GO:0007182
GO:0009887
GO:0045944
GO:0005667
GO:0005622
GO:0005634
GO:0003700
GO:0003712
GO:0007183
GO:0005737
GO:0008181
0005515
0005622
0005667
0006357
0007182
0007184
0009887
0009952
0010003
0016563
0045893
0045944
0051098
0003677
0003700
0003712
0005634
0005737
0006350
0006355
0007183
Alias MAD homolog 4 (Drosophila)
JIP
MAD (mothers against decapentaplegic Drosophila) homolog 4
Smad 4
SMAD, mothers against DPP homolog 4 (Drosophila)
D18Wsu70e
homolog of Drosophila Mothers against decapentaplegic,, 4
hSMAD4
MAD homolog 4
Madh4
Mothers against DPP homolog 4
Mothers against decapentaplegic homolog 4
Mothers against decapentaplegic, Drosophila, homolog of, 4
SMAD4
homolog of Drosophila Mothers against decapentaplegic,, IV
MAD (mothers against decapentaplegic, Drosophila) homolog IV
Mothers against decapentaplegic homolog IV
MAD homolog IV
MAD (mothers against decapentaplegic homolog IV
Mothers against decapentaplegic, Drosophila, homolog of, IV
Deletion target in pancreatic carcinoma IV
MAD (mothers against decapentaplegic homolog 4
Deletion target in pancreatic carcinoma 4
SMAD, mothers against DPP homolog 4
MAD, mothers against decapentaplegic homolog 4 (Drosophila)
SMAD, mothers against DPP homolog IV
MAD (mothers against decapentaplegic, Drosophila) homolog 4
Mothers against DPP homolog IV
hSMAD4s
DPC4
Organism Rattus norvegicus
Mus musculus
Homo sapiens
Human
MedLine Reference 12270938
12543979
12943993
14633973
15215210
15282343
15459107
9702197
10823886
10980615
LocusLink ID 28063
17128
4089
50554
FunctionalClass DNA binding
protein binding
transcriptional activator
transcription cofactor
transcription factor
RGD ID 3033
Hugo Symbol SMAD4
Unigene ID Rn.9774
Mm.100399
Hs.75862
KEGG pathway Adherens junction
Cell cycle
TGF-beta signaling pathway
Wnt signaling pathway
Keyword nucleus
nuclei
GO Cellular Component intracellular
transcription factor complex
cytoplasm
nucleus
GO Molecular Function protein binding
DNA binding
transcription factor activity
transcription cofactor activity
protein binding activity
DNA binding activity
tumor suppressor
Cell Localization Nucleus
Cytoplasm
Pathway Jnk-mapk
SAPK-JNK Signaling
TGF-beta signaling
TGFR2-TGFR1
TGFR2-ALK1
BMPR2-BMPR1B
BMPR2-BMPR1A
BMPR2-AcvR1
AMHR-BMPR1A
AMHR-AcvR1
AcvR2B-BMPR1B
AcvR2B-BMPR1A
AcvR2B-ALK7
AcvR2B-AcvR1B
AcvR2B-AcvR1
AcvR2-AcvR1
AMHR-BMPR1B
ACVR1 -> MADH4 signalling pathway
TGFBR1 -> MADH4 signalling pathway
MC1R -> MADH4 signalling pathway
BMP2-ACVR1
BMP2-ACVR2
BMP2-BMPR1A
BMP2-BMPR1B
BMP2-BMPR2
BMP4-ACVR1
BMP4-BMPR1A
BMP4-BMPR1B
BMP4-BMPR2
BMP7-ACVR1
BMP7-ACVR2
BMP7-ACVR2B
BMP7-BMPR1A
BMP7-BMPR1B
BMP7-BMPR2
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IGF1-BST1
IGF1-IGF2R
IGF1-LRP5
IL1B-HLA-DRB1
IL1B-IL1R1
IL1B-IL1RAP
IL1B-IL6R
INHBA-ACVR1B
INHBA-ACVR2
INHBA-ACVR2B
INHBA-ACVRL1
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1B
DuPont 4
PPAR all
PPARalpha
AR
ERbeta
ERalpha
HNF4a
GO Biological Process SMAD protein nuclear translocation
anterior/posterior pattern formation
common-partner SMAD protein phosphorylation
gastrulation (sensu Mammalia)
organogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-dependent
regulation of binding
regulation of transcription from RNA polymerase II promoter
SMAD protein heteromerization
regulation of transcription, DNA-dependent
transcription
positive regulation of transcription from Pol II promoter
regulation of transcription from Pol II promoter
Group Transcription factors
State p
MGI ID 894293
Swiss-Prot Accession Q13485
OMIM ID 600993
175050
174900
OMIM:600993
OMIM:175050
OMIM:174900
Source Curated
BIND
ResNet