| Name | POU1F1 |
|---|---|
| Description | POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) |
| Owner | Public |
| URN | urn:agi-llid:5449 |
| Connectivity | 44 |
| Notes | PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988 [PubMed 3215510]). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM] |
| Hugo ID | 9210 |
| Microarray ID | 1369761_at |
|---|---|
| 1369762_at | |
| l01507_at | |
| A_43_P11655 | |
| 1422220_at | |
| 98788_at | |
| d12885_s_at | |
| A_52_P318281 | |
| A_51_P352068 | |
| D10216 | |
| 34014_f_at | |
| 207846_at | |
| 34013_f_at | |
| D10216_s_at | |
| X62429_s_at | |
| A_23_P155539 | |
| A_14_P127208 | |
| A_14_P132146 | |
| A_24_P929909 | |
| OR3749 | |
| OH2317A | |
| RA0510 |
| Chromosome position | 11p12 |
|---|---|
| 3p11 | |
| 16 43.5 cM |
| GO ID | 0003700 |
|---|---|
| 0005634 | |
| 0006355 | |
| 0006366 | |
| 0008285 | |
| 0009887 | |
| 0003677 | |
| 0005515 | |
| 0005667 | |
| 0006350 | |
| 0045893 | |
| 0016563 |
| Alias | GHF1A |
|---|---|
| Pit1 | |
| Pituitary-specific positive transcription factor 1 | |
| POU domain, class 1, transcription factor 1 | |
| Pou1f1 | |
| Growth hormone factor I | |
| GHF1 | |
| PIT1Z | |
| Pituitary-specific positive transcription factor I | |
| Pit I | |
| Pou1f I | |
| pituitary specific transcription factor 1 | |
| pituitary specific transcription factor I | |
| GHF I | |
| Growth hormone factor 1 | |
| dwarf protein |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 2902928 |
|---|---|
| 1487156 | |
| 9392392 | |
| 9482665 | |
| 11891224 | |
| 12651892 |
| LocusLink ID | 25517 |
|---|---|
| 5449 | |
| 18736 |
| FunctionalClass | transcription factor |
|---|---|
| DNA binding | |
| protein binding | |
| transcriptional activator |
| RGD ID | 3367 |
|---|
| Hugo Symbol | POU1F1 |
|---|
| Unigene ID | Rn.10445 |
|---|---|
| Hs.89394 | |
| Mm.355440 |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex |
| Cell Localization | Nucleus |
|---|
| Pathway | GH1-GHR |
|---|---|
| GH1-IGF1R | |
| GH1-PRLR | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| PRL-PRLR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| PXR | |
| PPAR all | |
| PPARalpha | |
| ERalpha |
| GO Biological Process | transcription from Pol II promoter |
|---|---|
| negative regulation of cell proliferation | |
| organogenesis | |
| regulation of transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| positive regulation of transcription, DNA-dependent | |
| transcription |
| Group | Transcription factors |
|---|
| MGI ID | 97588 |
|---|
| Swiss-Prot Accession | P28069 |
|---|
| OMIM ID | 173110 |
|---|
| Source | Curated |
|---|