| Name | NCOA6 |
|---|---|
| Description | nuclear receptor coactivator 6 |
| Owner | Public |
| URN | urn:agi-llid:23054 |
| Connectivity | 33 |
| Notes | The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. |
| Hugo ID | 15936 |
| Microarray ID | A_14_P107934 |
|---|---|
| OH6668A | |
| OR2925 | |
| A_42_P487471 | |
| 1423374_at | |
| 95351_at | |
| 95525_at | |
| aa414339_at | |
| aa711633_s_at | |
| A_51_P521128 | |
| 40411_at | |
| 208979_at | |
| 1568874_at | |
| D80003_at | |
| A_23_P259135 | |
| A_14_P138063 | |
| A_14_P135123 |
| Chromosome position | 3q42 |
|---|---|
| 20q11 |
| GO ID | 0003713 |
|---|---|
| 0004872 | |
| 0001701 | |
| 0003682 | |
| 0005515 | |
| 0005634 | |
| 0005667 | |
| 0006260 | |
| 0006281 | |
| 0006310 | |
| 0006350 | |
| 0006355 | |
| 0006367 | |
| 0007420 | |
| 0007507 | |
| 0009725 | |
| 0016563 | |
| 0030099 | |
| 0030331 | |
| 0030374 | |
| 0030520 | |
| 0042921 | |
| 0045944 | |
| 0046965 | |
| 0046966 |
| Alias | RAP250 |
|---|---|
| Thyroid hormone receptor binding protein | |
| AIB3 | |
| RAP250s | |
| PRIP | |
| peroxisome proliferator-activated receptor interacting protein | |
| activating signal cointegrator-2 | |
| peroxisome proliferator-activated receptor interactive protein | |
| mKIAA0181 | |
| amplified in breast cancer-3 protein | |
| Ncoa7 | |
| nuclear receptor coactivator RAP250; peroxisome proliferator-act | |
| nuclear receptor coactivator RAP250; peroxisome proliferator-activated rece | |
| NRC | |
| Cancer-amplified transcriptional coactivator ASC II | |
| TRBP | |
| NCOA6 | |
| nuclear receptor coactivator RAP250 | |
| peroxisome proliferator-activated receptor interacting,PRIP | |
| peroxisome proliferator-act | |
| peroxisome proliferator-activated rece | |
| nuclear receptor coactivator VI | |
| ASC2 | |
| Cancer-amplified transcriptional coactivator ASC-2 | |
| KIAA0181 | |
| nuclear receptor coactivator 6 | |
| nuclear receptor-activating protein 250 | |
| Nuclear receptorcoactivator RAP250 |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 10681503 |
|---|---|
| 10788465 | |
| 12368298 | |
| 12446761 | |
| 12556486 | |
| 10866662 | |
| 10567404 | |
| 11302752 | |
| 11443112 | |
| 12519782 |
| LocusLink ID | 116464 |
|---|---|
| 23054 | |
| 107952 | |
| 56406 | |
| 50920 |
| FunctionalClass | chromatin binding |
|---|---|
| estrogen receptor binding | |
| ligand-dependent nuclear receptor transcription coactivator | |
| protein binding | |
| receptor | |
| transcription coactivator | |
| retinoid X receptor binding | |
| thyroid hormone receptor binding | |
| transcriptional activator |
| RGD ID | 620111 |
|---|
| Hugo Symbol | NCOA6 |
|---|
| Unigene ID | Mm.27592 |
|---|---|
| Hs.368971 | |
| Rn.9077 |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex |
| Cell Localization | Nucleus |
|---|
| Pathway | IFNA1-CR2 |
|---|---|
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| AR | |
| RXR | |
| ERalpha | |
| TR | |
| NR common regulators |
| GO Biological Process | positive regulation of transcription from Pol II promoter |
|---|---|
| myeloid blood cell differentiation | |
| transcription initiation from Pol II promoter | |
| DNA recombination | |
| DNA repair | |
| DNA replication | |
| brain development | |
| embryonic development (sensu Mammalia) | |
| estrogen receptor signaling pathway | |
| glucocorticoid receptor signaling pathway | |
| heart development | |
| myeloid cell differentiation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| response to hormone stimulus | |
| transcription | |
| transcription initiation from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| MGI ID | 1929915 |
|---|
| Swiss-Prot Accession | Q14686 |
|---|
| OMIM ID | 605299 |
|---|
| Source | Curated |
|---|