| Entities | PPARA ---- CYP8B1 |
|---|---|
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:inout-urn:agi-llid:1582::positive |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i37 p28947 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/37/28947 |
| MedLine Reference | 10867000:1136 |
| Sentence | These data establish that the identified PPRE in the rat sterol 12alpha-hydroxylase promoter region is capable of binding the PPARalpha/RXR heterodimer, although this PPRE appears to be weak compared with e.g. the ACO PPRE . |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i4 pG551 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/4/G551 |
| MedLine Reference | 12631556:1141 |
| Sentence | In the liver, PPARalpha appears to stimulate CYP8B1 and to decrease CYP7A1 expression ( 14 ). |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i50 p47154 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/50/47154 |
| MedLine Reference | 11606578:1046 |
| Sentence | Recent studies indicate that PPARalpha may exert regulatory control over CYP7A1 ( 29-31 ) and CYP8B1 ( 32 ), thereby potentially extending the physiological roles of this receptor. |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v45 i6 p1051 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/6/1051 |
| MedLine Reference | 15026425:1223 |
| Sentence | PPARalpha has also been shown to upregulate the expression of sterol 12alpha-hydroxylase and thereby regulate bile acid composition ( 24 ). |
| Organism | Mus musculus |