| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5465:out-urn:agi-cas:67254-79-9::unknown |
| Entities | PPARA ---> fatty acid |
| References | 20 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Organ | colon |
| MedLine Reference | 10811115:1301 |
| Sentence | Moreover, previous studies have shown that excessive levels of free fatty acids may be translocated into the nucleus to activate a target gene through PPAR- and may contribute to colon carcinogenesis (39 , 40 , 41) . |
| Journal | Cancer Res |
| Journal Reference | v60 i9 p2390 (2000) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/60/9/2390 |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 12649261:1039 |
| CellType | myocyte |
| Sentence | Specifically, exposure of myocytes to PPAR - or A?A?/ -specific agonists or long-chain fatty acids led to a significant induction of known PPAR target genes involved in fatty acid uptake and oxidation whereas a PPAR agonist had no effect. |
| Journal | Circulation Res |
| Journal Reference | v92 i5 p482 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/92/5/482 |
| Tissue | fat |
|---|---|
| Organism | Rattus norvegicus |
| MedLine Reference | 11334421:1245 |
| Sentence | The current demonstration that thiazolidinediones enhance FFA uptake by adipose tissue fits well with reports that PPAR agonists upregulate adipose tissue gene expression of molecules involved in FFA transport and metabolism, including a putative fatty acid transporter protein, fatty acid translocase, and acyl-CoA synthetase ( 10 , 20 ). |
| Journal | Diabetes |
| Journal Reference | v50 i5 p1158 (2001) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/50/5/1158 |
| MedLine Reference | 12746275:1049 |
|---|---|
| Sentence | Earlier studies have demonstrated that in the liver, PPARalpha directly regulates genes involved in fatty acid uptake [fatty acid binding protein (FATP)], beta-oxidation (acyl-CoA oxidase) and omega-oxidation (cytochrome P450). |
| Journal | Endocrinology |
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| Organ | liver |
|---|---|
| MedLine Reference | 11897617:1340 |
| Sentence | PPAR-alpha regulates genes involved in fatty acid uptake, activation to acyl-CoA esters, degradation via the peroxisomal and mitochondrial eta-oxidation pathways, and ketone body synthesis. |
| Journal | Gastr. Liver Phys |
| Journal Reference | v282 i4 pG586 (2002) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/282/4/G586 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | heart |
| MedLine Reference | 11454595:1028 |
| CellType | cardiomyocyte |
| Sentence | PPAR-alpha activation in cultured neonatal cardiomyocytes increases transcription of genes involved in FA transport and metabolism ( 6 , 32 , 33 ), but direct effects of PPAR-alpha ligands on terminally differentiated cardiomyocytes from adult hearts have not been investigated. |
| Journal | Heart Circul |
| Journal Reference | v281 i2 pH888 (2001) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/281/2/H888 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12623780:1058 |
| Sentence | In addition to inducing all the genes encoding enzymes of the classical fatty acid eta-oxidation pathway [e.g., acyl-CoA oxidase, very-long-chain and medium-chain acyl-CoA dehydrogenase, and 3-keto-acyl-CoA thiolase ( 66 )], PPAR-alpha also activates the genes necessary for cellular uptake of fatty acids (fatty acid transport protein) and their initial derivatization for entry into the eta-oxidation cycle (acyl-CoA synthetase) (for a review, see Ref. 76 ). |
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH1 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H1 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11606578:1033 |
| Sentence | No single high affinity natural ligand has been identified for PPARalpha, raising the possibility that PPARalpha may serve as a generalized cellular sensor of fatty acid flux. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i50 p47154 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/50/47154 |
| Organism | Mus musculus |
|---|---|
| Organ | heart |
| MedLine Reference | 15262994:1151 |
| CellType | myocyte |
| Sentence | Specifically, Cn* activated the expression of known PPARalpha target genes involved in fatty acid uptake ( e.g. CD36), mitochondrial beta-oxidation ( e.g. M-CPT I and II, VLCAD, LCAD, and MCAD), and peroxisomal beta-oxidation (acyl-CoA oxidase) ( Table I B ). |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i38 p39593 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/38/39593 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 15302862:1045 |
| Sentence | PPARalpha regulates genes involved in gluconeogenesis as well as fatty acid transport and beta-oxidation ( 8 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p46204 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/46204 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 9341179:1164 |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i43 p27307 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/43/27307 |
| Tissue | fat |
|---|---|
| Organism | Mus musculus |
| Organ | liver |
| MedLine Reference | 9353271:1041 |
| CellType | adipocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i45 p28210 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/45/28210 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 12065722:1032 |
| Journal | JPET |
| Journal Reference | v302 i1 p232 (2002) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/302/1/232 |
| Tissue | skeletal muscle |
|---|---|
| Organ | heart |
| MedLine Reference | 10431661:4 |
| Organism | Mus musculus |
|---|---|
| Organ | heart |
| MedLine Reference | 11781357:2 |
| Organ | heart |
|---|---|
| MedLine Reference | 12425323:3 |
| CellLineName | FA |
| Organism | Mus musculus |
|---|---|
| Organ | intestine |
| MedLine Reference | 12077340:1027 |
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i14 p5114 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/14/5114 |
| Tissue | skeletal muscle |
|---|---|
| Organism | Mus musculus |
| Organ | heart |
| MedLine Reference | 15456881:1344 |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i20 p9079 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/20/9079 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 11158336:1127 |
| Journal | Mol. Endocrin |
| Journal Reference | v15 i2 p308 (2001) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/15/2/308 |
| Organism | Mus musculus |
|---|---|
| Organ | kidney |
| MedLine Reference | 15075187:1222 |
| Journal | Renal Phys |
| Journal Reference | v286 i5 pF913 (2004) |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/286/5/F913 |
| CellLineName | db |