| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5465:out-urn:agi-cas:57-88-5::unknown |
| Entities | cholesterol <--- PPARA |
| References | 13 |
| Connectivity | 2 |
| Effect | unknown |
| MedLine Reference | 11742860:1062 |
|---|---|
| Sentence | An important question regards the role of PPAR in VSMCs and ECs and whether reverse cholesterol transport plays an important role in attenuation of the atherosclerotic process by PPAR ligands. |
| Journal | ATVB |
| Journal Reference | v21 i12 p1891 (2001) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/21/12/1891 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12615680:1143 |
| CellType | macrophage |
| Sentence | PPAR activators stimulate cholesterol efflux from cells by activating transcription of the LXR gene, which in turn induces ABCA1 transcription. 66,67 View this table: [in this window] [in a new window] Table 1. |
| Journal | ATVB |
| Journal Reference | v23 i5 p720 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/5/720 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12615696:1035 |
| CellType | macrophage |
| Sentence | PPAR activators also modulate cholesterol efflux by regulating the gene expression of ATP-binding cassette proteins A1 (ABCA1) and G1 (ABCG1). 22 , 24 , 25 The integral role of ABCA1 in regulating cellular cholesterol transport is exemplified by loss-of-function mutations causing Tangier disease, which is characterized by significant cholesterol accumulation in macrophages. 26 , 27 ABCA1 expression is upregulated by PPAR ligands through a transcriptional cascade mediated by the nuclear hormone receptor, liver X receptor (LXR ). 22 The LXR gene contains a PPRE, so that on PPAR activation, LXR expression is induced. |
| Journal | ATVB |
| Journal Reference | v23 i3 p475 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/3/475 |
| MedLine Reference | 14592855:1077 |
|---|---|
| CellType | macrophage |
| Sentence | PPARalpha has also been suggested to stimulate cholesterol efflux from macrophage-derived foam cells by upregulation of CLA-1/scavenger receptor class B type I (SR-BI). 80 However, studies in vitro show that PPARalpha and PPARgamma have the potential to downregulate the expression of macrophage cholesteryl ester hydrolase, 79,81 an enzyme responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for HDL-mediated efflux. |
| Journal | ATVB |
| Journal Reference | v24 i2 p230 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/2/230 |
| MedLine Reference | 12574149:1015 |
|---|---|
| CellType | macrophage |
| Sentence | Recently, it was shown that PPAR activation promotes cholesterol efflux from macrophages via induction of the ABCA1 pathway. |
| Journal | Circulation Res |
| Journal Reference | v92 i2 p212 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/92/2/212 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12623780:1089 |
| Sentence | Stimulation of the phospholipid transporter MDR2 could be a final point where PPAR-alpha agonists affect reverse cholesterol transport, by favoring the excretion of phospholipids and associated cholesterol from the liver into bile ( 48 ) PPAR-alpha AND THE HEART TOP ABSTRACT CLINICAL USE OF PPAR-{alpha}... |
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH1 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H1 |
| MedLine Reference | 11861659:1224 |
|---|---|
| CellType | macrophage |
| Sentence | Thus, PPAR may be an important modifier of the reverse cholesterol transport pathway. |
| Journal | Lipid Res |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12576508:1146 |
| Sentence | A recent study has provided evidence to support the direct action of activated PPAR on steroidogenic cells such as Leydig cells, where PPAR inhibits steroidogenesis through suppression of the transport of cholesterol into the mitochondria ( 13 ). |
| Journal | Lipid Res |
| Journal Reference | v44 i2 p265 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/265 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 12897186:1022 |
| Sentence | These results suggest that PPARalpha influences cholesterol absorption through modulating ABCA1 activity in the intestine by a mechanism involving LXRalpha. |
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2049 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| MedLine Reference | 11135616:7 |
|---|---|
| CellType | macrophage |
| Sentence | Moreover, PPAR-alpha and PPAR-gamma activators increase apoAI-induced cholesterol efflux from normal macrophages. |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11909955:1023 |
| CellType | macrophage |
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i8 p2607 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/8/2607 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12730331:1243 |
| CellType | macrophage |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| MedLine Reference | 15087471:1243 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |