| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5465:out-urn:agi-smol:1808964::unknown |
| Entities | lipids <--- PPARA |
| References | 9 |
| Connectivity | 2 |
| Effect | unknown |
| Organ | liver |
|---|---|
| MedLine Reference | 12006382:1022 |
| Sentence | PPAR controls plasma lipid transport by acting on triglyceride and fatty acid metabolism and by modulating bile acid synthesis and catabolism in the liver. |
| Journal | ATVB |
| Journal Reference | v22 i5 p717 (2002) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/5/717 |
| MedLine Reference | 11861425:1022 |
|---|---|
| CellType | adipocyte |
| Sentence | This complex binds to the PPAR-responsive element, PPRE, within the promoters of PPAR -target genes. 12 , 13 PPAR has been known to be essential for adipocyte differentiation and the control of cellular lipid uptake. 14 Recent studies have demonstrated that PPAR is expressed at high levels in the foam cells in atherosclerotic lesions and can promote differentiation of monocytes to macrophages. 15 Furthermore, it has been reported that PPAR agonists suppress the elaboration of inflammatory cytokines from macrophages. 16 , 17 These lines of evidence suggest that Tro or PPAR ligands regulate the development and progression of atherosclerosis. |
| Journal | Circulation Res |
| Journal Reference | v90 i3 p348 (2002) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/90/3/348 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | heart |
| MedLine Reference | 12649261:1026 |
| Sentence | As a fatty acid-activated transcription factor, PPAR also serves to match cardiac lipid delivery to oxidative capacity, a "lipostat" function. |
| Journal | Circulation Res |
| Journal Reference | v92 i5 p482 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/92/5/482 |
| Tissue | skeletal muscle |
|---|---|
| Organ | liver |
| MedLine Reference | 11557505:1052 |
| Sentence | In general, PPAR-alpha activation leads to the induction of several genes encoding proteins involved in lipid transport, oxidation, and thermogenesis including hepatic carnitine palmitoyltransferase, hepatic and skeletal muscle peroxisomal acyl-CoA oxidase, and muscle uncoupling protein-3 ( 1 , 3 , 13 , 20 ). |
| Journal | Gastr. Liver Phys |
| Journal Reference | v281 i4 pG865 (2001) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/281/4/G865 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 11705737:1104 |
| Sentence | Thus PPARalpha appears to be a xenosensor as well as a sensor of fluxes in certain lipid moieties in liver ( 7 ). |
| Journal | Gastr. Liver Phys |
| Journal Reference | v281 i6 pG1333 (2001) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/281/6/G1333 |
| Organ | prostate |
|---|---|
| MedLine Reference | 11861659:1031 |
| CellType | macrophage |
| Sentence | PPAR signaling pathways are now recognized to be involved in the control of lipid uptake, transport, storage, and disposal. |
| Journal | Lipid Res |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12235171:1031 |
| Sentence | Consistent with this finding, an isomeric CLA mixture induced the expression of typical PPAR target genes encoding proteins involved in hepatic lipid transport (liver fatty acid-binding protein or L-FABP) and catabolism (acyl-CoA oxidase, and cytochrome P450 4A1) ( 19 ). |
| Journal | Lipid Res |
| Journal Reference | v43 i9 p1400 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/9/1400 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | placenta |
| MedLine Reference | 12361685:8 |
| Sentence | The presence of PPAR and RXR isoforms in both the rat and human placentas suggest that PPAR and RXR isoforms are potential regulators of placental lipid transfer and homeostasis. |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11909955:1040 |
| CellType | macrophage |
| Sentence | A number of previous studies examining the role of PPAR in regulating lipid flux in macrophages have been performed by using macrophage cancer cell lines and macrophages derived from embryonic stem (ES) cells. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i8 p2607 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/8/2607 |
| CellLineName | ES |