| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:1553-41-9:out-urn:agi-llid:5465::positive |
| Entities | EPA --+> PPARA |
| References | 5 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 10493929:7 |
| Sentence | Both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) activated GR-PPARalpha. |
| Organism | Mus musculus |
|---|---|
| CellType | monocyte |
| Tissue | endothelial |
| MedLine Reference | 12149216:3 |
| Sentence | In transcriptional coactivation assays, oxidized EPA potently activated the peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the nuclear receptor family. |
| Journal | Nutrition |
|---|---|
| Journal Reference | v129 i2 p575S (1999) |
| Journal Link | http://www.nutrition.org/cgi/content/full/129/2/575S |
| MedLine Reference | 10024656:1184 |
| Sentence | However, fatty acids such as CLA, DHA and EPA have anticancer activity in extrahepatic tissues and are known PPAR activators. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | bewo |
| Journal | Lipid Res |
| Journal Reference | v42 i5 p743 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/5/743 |
| MedLine Reference | 11352981:1171 |
| Sentence | Northern blot analysis showed that 0.5 mM OA, EPA, and DHA for 48 h reduced the expression of PPAR mRNA to 55 A?A± 7%, 28 A?A± 6%, and 31 A?A± 11%, respectively ( Fig 4 ). |
| Organ | liver |
|---|---|
| MedLine Reference | 9610365:6 |
| Sentence | In addition, PPAR alpha expression was also increased by benzafibrate or eicosapentaenoic acid with the physiological concentration. |