| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:124083-20-1:out-urn:agi-llid:5465::positive |
| Entities | etomoxir --+> PPARA |
| References | 2 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| CellLineName | C2C12 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i12 p10100 (2002) |
| Tissue | skeletal muscle |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10100 |
| MedLine Reference | 11792699:1134 |
| Sentence | To further clarify the potential involvement of ceramides in the down-regulation of PPARalpha caused by etomoxir, we treated C2C12 skeletal muscle cells with C 2 -ceramide, a cell-permeable ceramide analog, for 24 h. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i2 p388 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/388 |
| Organ | heart |
| MedLine Reference | 12576521:1013 |
| Sentence | Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) that activates peroxisome proliferator-activated receptor (PPAR ) and induces cardiac hypertrophy through an unknown mechanism. |