| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:882-09-7:out-urn:agi-llid:5465::positive |
| Entities | clofibric acid --+> PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | COS I |
|---|---|
| Journal | Eur. J. Biochem |
| Journal Reference | v267 i13 p4063 (2000) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/267/13/4063 |
| MedLine Reference | 10866807:1026 |
| Sentence | However, stimulation of PPARalpha and all RXRs by clofibric acid and 9- cis -retinoic acid was observed in transient transfection assays. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Nutrition |
| Journal Reference | v131 i3 p841S (2001) |
| Journal Link | http://www.nutrition.org/cgi/content/full/131/3/841S |
| Organ | liver |
| MedLine Reference | 11238771:1198 |
| Sentence | Clofibric acid also induces large increases in PDK4 expression in several rat tissues (Wu, P. and Harris, R. A., unpublished results), suggesting naturally occurring PPAR ligands, such as fatty acids, may signal increased PDK4 gene expression. |
| Organism | Rattus norvegicus |
|---|---|
| CellType | hepatocyte |
| MedLine Reference | 9354589:6 |
| Sentence | It was found that IL-1beta and IL-6 both repress the induction of PPAR alpha expression exerted by the combined action of clofibric acid and dexamethasone. |
| CellLineName | IMR-32 |
|---|---|
| MedLine Reference | 11074598:7 |
| Sentence | In support of this hypothesis, clofibric acid, a specific ligand of PPARalpha, also inhibited IMR-32 cell proliferation and strongly induced PPAR activation. |