| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:637-07-0:out-urn:agi-llid:5465::positive |
| Entities | clofibrate --+> PPARA |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i5 p812 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/5/812 |
| Organ | liver |
| MedLine Reference | 14993239:1332 |
| Sentence | Clofibrate is known to stimulate PPARalpha and thereby enhance the expression of enzymes associated with peroxisomal fatty acid oxidation ( 43 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | HTB9 |
| MedLine Reference | 12890579:5 |
| Sentence | The results indicate that PPARalpha was able to induce SCPx promoter activity in both cases, an effect that was enhanced by RXR and clofibrate. |
| Journal | Reg.Int.Comp.Phys |
|---|---|
| Journal Reference | v281 i5 pR1553 (2001) |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/281/5/R1553 |
| Organ | liver |
| MedLine Reference | 11641128:1185 |
| Sentence | Peroxisome proliferators also induce transcription of the regulatory enzyme of ketogenesis, mitochondrial hydroxymethylglutaryl-CoA synthase, the gene of which possesses a PPRE responsive to PPAR-alpha that is activated by clofibrate ( 38 , 45 ). |
| CellLineName | U373 MG |
|---|---|
| Journal | J. Biol. Chem |
| CellType | astrocyte |
| Journal Reference | v277 i48 p45984 (2002) |
| Tissue | astroglia |
| Journal Link | http://www.jbc.org/cgi/content/full/277/48/45984 |
| MedLine Reference | 12244038:1127 |
| Sentence | Clofibrate is also a hypolipidemic drug that activates PPAR-alpha and induces proliferation of peroxisomes in rats and mice ( 9 , 20 , 21 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Cell Growth and Diff |
| CellType | keratinocyte |
| Journal Reference | v11 i8 p447 (2000) |
| Journal Link | http://cgd.aacrjournals.org/cgi/content/full/11/8/447 |
| MedLine Reference | 10965849:1137 |
| Sentence | Two members of the fibrate class of drugs, clofibrate and cibrofibrate, have been reported to be PPAR activators (17) . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i3 pG423 (2003) |
| Tissue | fat |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G423 |
| Organ | liver |
| MedLine Reference | 12444013:1238 |
| Sentence | Clofibrate is one of the peroxisome proliferator-activated receptor alpha activators, which induce ectopic expression of L-FABP mRNA (higher level) and adipose-FABP mRNA (lower level) in the liver ( 30 ). |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 14690017:8 |
| Sentence | Clofibrate also enhanced the expression of mRNAs for PPARalpha, LXRalpha, and ABCA1. |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 15200495:7 |
| Sentence | Both HFD and clofibrate induced PPARalpha expression, clofibrate induction being more prominent than HFD. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | McA-RH7777 |
| MedLine Reference | 15319530:4 |
| Sentence | In McA-RH7777 cells, clofibrate alone mediated a higher induction of PPARalpha expression than linoleic acid. |
| Organism | Mus musculus |
|---|---|
| Journal | JPET |
| Journal Reference | v297 i3 p895 (2001) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/297/3/895 |
| MedLine Reference | 11356909:1166 |
| Sentence | Both peroxisome proliferators, DEHP and clofibrate, induced a number of genes involved in fatty acid eta-oxidation that are linked to the activation of the PPAR. |
| CellLineName | SW |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v42 i5 p716 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/5/716 |
| MedLine Reference | 11352978:1020 |
| MedLine Reference | 12740825:0 |
|---|