| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:122320-73-4:out-urn:agi-llid:5465::positive |
| Entities | rosiglitazone --+> PPARA |
| References | 6 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Cancer Res |
| CellType | adipocyte |
| Journal Reference | v62 i11 p3282 (2002) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/62/11/3282 |
| MedLine Reference | 12036946:1020 |
| Sentence | Many chemical agents, including the thiazolidinediones, rosiglitazone (BRL-49653), and pioglitazone, can also bind and activate PPAR (6 , 7 , 9 , 10 , 11) . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Hypertension |
| Journal Reference | v38 i2 p249 (2001) |
| Tissue | vascular |
| Journal Link | http://hyper.ahajournals.org/cgi/content/full/38/2/249 |
| MedLine Reference | 11509485:1033 |
| Sentence | We recently observed that docosahexaenoic acid 12 and rosiglitazone (unpublished data, 2000), which are a PPAR- activator and a PPAR- ligand, respectively, induce apoptosis in VSMCs. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | rasmc |
| Tissue | smooth muscle |
| Organ | aorta |
| MedLine Reference | 12897060:6 |
| Sentence | In contrast, indomethacin, an alternative inhibitor of cyclooxygenase activity, inhibited both rosiglitazone-induced cell death, and rosiglitazone-induced PPAR reporter gene activation. |
| Organism | Mus musculus |
|---|---|
| Tissue | fat |
| Organ | liver |
| MedLine Reference | 14709251:9 |
| Sentence | Ritonavir partially inhibited induction of PPAR target genes by gemfibrozil and rosiglitazone. |
| CellLineName | JEG3 |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i6 p1586 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/6/1586 |
| MedLine Reference | 14645690:1021 |
| Sentence | The PPAR-gamma-specific ligand rosiglitazone induced PPAR response element (PPRE)-mediated activity in a concentration-dependent manner, whereas the PPAR-gamma-specific irreversible inhibitor GW9662 fully inhibited this induction. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrin. Metabol |
| CellType | adipocyte |
| Journal Reference | v284 i4 pE841 (2003) |
| Tissue | fat |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/4/E841 |
| MedLine Reference | 12475752:1261 |
| Sentence | In the adipose tissue, treatment with either ragaglitazar or rosiglitazone led to increased expression of known adipocyte PPAR target genes. |