| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:97322-87-7:out-urn:agi-llid:5465::positive |
| Entities | troglitazone --+> PPARA |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | lncap |
|---|---|
| Journal | Cancer Res |
| Journal Reference | v60 i19 p5494 (2000) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/60/19/5494 |
| MedLine Reference | 11034093:1132 |
| Sentence | Furthermore, neither DHT nor troglitazone affected levels of PPAR (Fig. 5) . |
| Organism | Mus musculus |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | Mol. Endocrin |
| Journal Reference | v14 i2 p307 (2000) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/2/307 |
| MedLine Reference | 10674402:1153 |
| Sentence | When PPAR 2 cDNA was cotransfected, troglitazone-dependent enhancement of the promoter activity was observed. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Diabetes |
| Journal Reference | v50 i5 p1093 (2001) |
| Tissue | skeletal muscle |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/50/5/1093 |
| MedLine Reference | 11334413:1023 |
| Sentence | TGZ was recently reported to upregulate PPAR- gene expression in skeletal muscle of patients with type 2 diabetes ( 8 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Nutrition |
| Journal Reference | v129 i3 p602 (1999) |
| Tissue | fat |
| Journal Link | http://www.nutrition.org/cgi/content/full/129/3/602 |
| MedLine Reference | 10082762:1139 |
| Sentence | Using a transfection study, they demonstrated that CLA and troglitazone can activate PPAR transcription. |
| Journal | Diabetes |
|---|---|
| Journal Reference | v51 i4 p1060 (2002) |
| Tissue | skeletal muscle |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/51/4/1060 |
| MedLine Reference | 11916926:1117 |
| Sentence | In cells treated with 11.5 A?Aµmol troglitazone for 4 days, PPAR 2 mRNA levels were significantly ( P < 0.05, paired t test) increased to 301.0 A?A± 51.5% of the untreated controls ( Fig. 5 A ), and -6 desaturase mRNA levels were significantly ( P < 0.0005, paired t test) decreased to 41.7 A?A± 5.9% of the untreated controls ( Fig. 5 B ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | FAO |
| Journal | Lipid Res |
| Journal Reference | v40 i8 p1426 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/8/1426 |
| MedLine Reference | 10428978:1162 |
| Sentence | Troglitazone (a PPAR selective activator) did not cause any change in CYP4A1 protein corroborating the low expression of PPAR in FaO cells. |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 11172467:3 |
| Sentence | Troglitazone and pioglitazone, which are ligands/activators for PPARgamma, also induced PPARalpha gene and protein expression and increased CuZn-SOD gene expression and protein levels in addition to increasing PPARgamma gene and protein expression in endothelial cells. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v14 i1 p27 (2000) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/1/27 |
| MedLine Reference | 10628745:1112 |
| Sentence | Full dose-response analysis showed that troglitazone activated human PXR with an EC 50 value of approximately 3 A?Aµ M , which is comparable to the concentration required to activate PPAR (data not shown). |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v16 i6 p1269 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1269 |
| MedLine Reference | 12040014:1083 |
| Sentence | Furthermore, troglitazone, an antidiabetic agent that increases glucose tolerance and insulin sensitivity, has previously been shown to be an activator of PPAR and to increase GLUT2 protein levels ( 14 , 15 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | HeLa |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i11 p2628 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/11/2628 |
| MedLine Reference | 12403851:1047 |
| Sentence | However, SR-202 showed a dose-dependent attenuation of troglitazone-induced PPAR transcriptional activity, with an IC50 of 140 A?Aµ M (Fig. 1E ). |
| Journal | Hypertension |
|---|---|
| Journal Reference | v40 i5 p748 (2002) |
| Journal Link | http://hyper.ahajournals.org/cgi/content/full/40/5/748 |
| MedLine Reference | 12411472:1149 |
| Journal | J. Immunol |
|---|---|
| Journal Reference | v164 i12 p6503 (2000) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/164/12/6503 |
| MedLine Reference | 10843708:1123 |