| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:50-99-7:out-urn:agi-llid:5465::negative |
| Entities | glucose ---| PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| CellType | macrophage |
| Journal Reference | v20 i1 p104 (2000) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/20/1/104 |
| MedLine Reference | 10634806:1142 |
| Sentence | The molecular mechanism(s) by which glucose upregulates macrophage PPAR and PPARA?A? mRNA levels is presently unknown. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i46 p35799 (2000) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/275/46/35799 |
| MedLine Reference | 10967113:1017 |
| Sentence | Chronic elevated glucose reduces the expression levels of the PPAR target genes, uncoupling protein 2 and acyl-CoA oxidase, which are involved in fat oxidation and lipid detoxification. |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| CellType | monocyte |
| Journal Reference | v24 i5 p851 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/5/851 |
| MedLine Reference | 15001458:1124 |
| Sentence | Glucose decreases PPARalpha expression in EC. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 (2002) |
| Tissue | islet |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| MedLine Reference | 12032169:1241 |
| Sentence | Glucose decreases PPAR expression in A?A? cells ( 20 ). |