| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:87893-55-8:out-urn:agi-llid:5465::positive |
| Entities | 15d-PGJ-2 --+> PPARA |
| References | 6 |
| Connectivity | 2 |
| Effect | positive |
| Journal | J. Immunol |
|---|---|
| CellType | macrophage |
| Journal Reference | v168 i9 p4747 (2002) |
| Tissue | blood |
| Journal Link | http://www.jimmunol.org/cgi/content/full/168/9/4747 |
| MedLine Reference | 11971025:1033 |
| Sentence | In stimulated murine and human peripheral blood macrophages, 15d-PGJ 2 binds to and activates PPAR , resulting in various anti-inflammatory events such as inhibition of iNOS, COX-2, gelatinase b expression, and inflammatory cytokine production ( 21 , 22 , 23 ). |
| Journal | ATVB |
|---|---|
| Journal Reference | v19 i3 p546 (1999) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/19/3/546 |
| Organ | aorta |
| MedLine Reference | 10073956:1108 |
| Sentence | PPAR activator 15d-PGJ 2 activates PPAR in bovine aortic ECs. |
| Journal | J. Immunol |
|---|---|
| Journal Reference | v164 i12 p6503 (2000) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/164/12/6503 |
| MedLine Reference | 10843708:1123 |
| Sentence | The mechanism for this effect is likely to be through PPAR activation, given prior evidence that troglitazone, BRL496553, and 15d-PGJ 2 are all PPAR activators with little activity for other PPAR forms. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v41 i5 p688 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/5/688 |
| MedLine Reference | 10787429:1150 |
| Sentence | Importantly, the increase in PPAR- mRNA expression induced by 15d-PGJ 2 was completely abolished in the presence of PKC inhibitors ( Fig 7a ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | adipocyte |
| Journal Reference | v12 i8 p1150 (1998) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/8/1150 |
| MedLine Reference | 9717841:1126 |
| Sentence | In summary, both 15d-PGJ 2 and BRL 49653 decreased PPAR 2 protein expression at 24 h in differentiated adipocytes, which is contrary to their previously reported actions in preadipocytes ( 21 ). |
| CellLineName | ZR-75 I |
|---|---|
| Journal | Cancer Res |
| Journal Reference | v63 i13 p3531 (2003) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/63/13/3531 |
| MedLine Reference | 12839938:1199 |
| Sentence | Thus, 15d-PGJ2 acts as an antagonist of PPAR with respect to the induction of RARA?A? by ciglitazone. |