| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:5465::negative |
| Entities | PPARA |--- PPARD |
| References | 4 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11867749:4 |
| Sentence | Stable expression of PPARdelta inhibits the expression of endogenous PPARalpha target gene expression in 3T3-PPARalpha cells, whereas a PPARdelta mutant that does not interact with the corepressor SMRT loses its ability to repress the induction of PPARalpha target gene. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | cardiomyocyte |
| Journal Reference | v271 i44 p27670 (1996) |
| Tissue | epithelia |
| Journal Link | http://www.jbc.org/cgi/content/full/271/44/27670 |
| Organ | kidney |
| MedLine Reference | 8910358:1033 |
| Sentence | Instead of activation, the human PPARdelta has been found to repress the activation of PPARalpha, as well as thyroid hormone receptor ( 16 ). |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i8 p4666 (1996) |
| Tissue | skeletal muscle |
| Journal Link | http://www.pnas.org/cgi/content/full/100/8/4666 |
| MedLine Reference | 12677001:1186 |
| Sentence | PPARD also negatively modulates PPARA and PPARG activity, both encoding proteins that positively regulate fatty acid metabolism in skeletal muscle ( 28 , 29 ). |
| MedLine Reference | 14646253:2 |
|---|---|
| Sentence | We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive. |