| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-protfc:tumor%20necrosis%20factor::negative |
| Entities | tumor necrosis factor |--- PPARA |
| References | 3 |
| Connectivity | 2 |
| Effect | negative |
| Journal | J. Immunol |
|---|---|
| CellType | macrophage |
| Journal Reference | v164 i12 p6503 (2000) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/164/12/6503 |
| MedLine Reference | 10843708:1027 |
| Sentence | In monocytes and monocyte-derived macrophages, activation of PPAR inhibits the expression of TNF- , IL-1 , IL-6, inducible nitric oxide synthase, gelatinase B/matrix metalloproteinase-9, and scavenger receptor A ( 9 , 10 , 11 ). |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 10377130:7 |
| Sentence | Utilizing PPARalpha wild-type (WT) and knockout (KO) mice, we showed that the effect of fenofibrate on LPS-induced TNF expression was indeed mediated by PPARalpha. |
| Journal | Circulation Res |
|---|---|
| CellType | t cell |
| Journal Reference | v90 i6 p703 (2002) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/90/6/703 |
| MedLine Reference | 11934839:1016 |
| Sentence | PPAR activators also inhibited TNF and interleukin-2 protein expression. |