| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:3458::unknown |
| Entities | IFNG <--- PPARA |
| References | 3 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Journal | J. Immunol |
| CellType | t cell |
| Journal Reference | v171 i1 p196 (2003) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/171/1/196 |
| MedLine Reference | 12816998:1014 |
| Sentence | We report that activated CD4+ T cells lacking PPARalpha produce increased levels of IFN-gamma, but significantly lower levels of IL-2 when compared with activated wild-type CD4+ T cells. |
| Organism | Mus musculus |
|---|---|
| Tissue | lymph |
| MedLine Reference | 14580308:5 |
| Sentence | We recently discovered that PPARalpha transiently suppresses the transcription of gamma-interferon (IFNgamma) by inhibiting the induction of T-bet. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v276 i36 p33471 (2001) |
| Tissue | smooth muscle |
| Journal Link | http://www.jbc.org/cgi/content/full/276/36/33471 |
| Organ | aorta |
| MedLine Reference | 11418615:1244 |
| Sentence | Indeed, PPARalpha activators lower plasma concentrations of IL-6, tumor necrosis factor alpha, and interferon gamma in patients with atherosclerosis ( 24 , 25 ) and suppress cytokine-stimulated IL-6 production in human aortic smooth muscle cells ( 25 ), inducible nitric-oxide synthase activity in murine macrophages ( 46 ), and vascular cell adhesion molecule-1 expression in endothelial cells ( 47 ). |