| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:55554::unknown |
| Entities | KLK15 <--- PPARA |
| References | 8 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | hepatocyte |
| Journal Reference | v271 i3 p1764 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/3/1764 |
| MedLine Reference | 8576180:1170 |
| Sentence | It was thus possible to test if an increase of the amount of PPARalpha protein could potentiate the stimulation of the ACO gene expression by WY-14,643, a well characterized peroxisome proliferator and activator of PPARalpha( 8 ) . |
| CellLineName | SW |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v42 i5 p716 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/5/716 |
| MedLine Reference | 11352978:1293 |
| Sentence | Although PPAR ligands have the ability to induce the ACO gene in rodents, their ability to induce the ACO gene in human cells has not been established ( 56 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i3 p764 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/3/764 |
| Organ | heart |
| MedLine Reference | 12920214:1214 |
| Sentence | Alternative mechanisms not directly involving PPAR may also participate in the regulation of ACO gene expression after troglitazone treatment. |
| Organism | Mus musculus |
|---|---|
| Journal | Nutrition |
| Journal Reference | v134 i4 p861 (2004) |
| Journal Link | http://www.nutrition.org/cgi/content/full/134/4/861 |
| Organ | liver |
| MedLine Reference | 15051838:1143 |
| Sentence | Some studies suggested that FA and acyl derivatives upregulate the expression of both L-CPT I and ACO genes through PPAR ( 36 A? 38 ), but other findings showed that long-chain FA regulate L-CPT I through a PPARalpha-independent pathway ( 39 , 40 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Renal Phys |
| Journal Reference | v275 i5 pF777 (1998) |
| Tissue | fat |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/275/5/F777 |
| Organ | gastric |
| MedLine Reference | 9815135:1182 |
| Sentence | In fact, cotransfection experiments indicate that, after activation by fatty acids, PPARalpha mediates transcriptional stimulation of MCAD, ACO, and other genes involved in fatty acid catabolism ( 27 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | PNAS |
| Journal Reference | v96 i5 p2391 (1999) |
| Journal Link | http://www.pnas.org/cgi/content/full/96/5/2391 |
| Organ | liver |
| MedLine Reference | 10051652:1103 |
| Sentence | These changes suggest that the increase in PPARalpha mediated the up-regulation of ACO and CPT-1 and that the reduced PPARgamma played a role in down-regulating the lipogenic enzymes. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i46 p35799 (2000) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/275/46/35799 |
| MedLine Reference | 10967113:1267 |
| Sentence | Because the ACO ( 52 ) and UCP2 ( 53 ) genes contain PPRE in their promoters and are regulated by PPARalpha ( 26 ), it is tempting to suggest that the glucose-induced down-regulation of PPARalpha in the eta-cell might be implicated in the redirection of lipid metabolism from fat oxidation to esterification during hyperglycemia ( 1 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | FAO |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p45512 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/45512 |
| MedLine Reference | 15337740:1143 |
| Sentence | By contrast, deletion of the PPARalpha gene fully abolished the statin-mediated up-regulation of L-FABP expression (mRNA and protein levels, Fig. 4, A and B ), ACO mRNA levels ( Fig. 4 C ) and the decrease of plasma TG ( Fig. 5 ), demonstrating the crucial role of PPARalpha in the induction of L-FABP gene expression by statins. |