| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-protfc:malic%20enzyme::unknown |
| Entities | malic enzyme <--- PPARA |
| References | 5 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| CellLineName | HepG 2 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i30 p27950 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/30/27950 |
| MedLine Reference | 11371553:1215 |
| Sentence | The lipogenic malic enzyme gene is regulated by PPARalpha in rats ( 47 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v138 i9 p3727 (1997) |
| Tissue | thyroid |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/9/3727 |
| MedLine Reference | 9275058:1220 |
| Sentence | As malic enzyme is also controlled by the peroxisome proliferator-activated receptor (PPAR) ( 49 ), it appears that malic enzyme expression is regulated by multiple nuclear receptors, including the T3 receptor, PPAR, and the aryl hydrocarbon receptor. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i21 p16390 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/21/16390 |
| Organ | liver |
| MedLine Reference | 10747970:1240 |
| Sentence | In fact, prior studies have shown that the expression of the malic enzyme, which is regulated by PPAR ( 58 ) and thyroid hormone receptor ( 59 ), is decreased after liver injury ( 60 ), supporting this hypothesis. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i36 p28285 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28285 |
| Organ | liver |
| MedLine Reference | 10866995:1108 |
| Sentence | In contrast to the AOX , MCAD , and malic enzyme genes, the basal transcription of the CYP4A1 and LFABP genes can be controlled by PPARalpha/RXRalpha at the physiological level. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v273 i10 p5678 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/10/5678 |
| MedLine Reference | 9488698:1159 |
| Sentence | In addition to the peroxisomal eta-oxidation enzymes and microsomal fatty acid hydroxylase P450, liver fatty acid binding protein and the genes encoding MCAD ( 43 ), 3-hydroxy-3-methylglutaryl-CoA synthase ( 44 ), and ME ( 45 ) are also activated by PPARalpha as indicated by transactivation assays. |