| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:6720::negative |
| Entities | SREBF1 |--- PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | negative |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v274 i33 p23577 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/33/23577 |
| Organ | liver |
| MedLine Reference | 10438539:1123 |
| Sentence | Is the Suppression of SREBP-1 Expression by PUFA Mediated by PPARalpha?-- Although the PUFA suppression of lipogenic genes does not appear to directly involve a PPARalpha-mediated mechanism ( 22 , 23 ), PUFA activation of hepatic PPARalpha could be responsible for the suppression of SREBP-1 expression. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i46 p32725 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/46/32725 |
| Organ | liver |
| MedLine Reference | 10551830:1118 |
| Sentence | To access the contribution PPARalpha makes to the regulation of hepatic SREBP1 gene expression, rats were fed a high carbohydrate diet supplemented with the PPARalpha activators gemfibrozil (0.2% w/w) or WY14,643 (0.1% w/w) for 7 days. |
| Organism | Mus musculus |
|---|---|
| CellLineName | HEK 293 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i3 p1705 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/3/1705 |
| MedLine Reference | 11694526:1130 |
| Sentence | No suppression of the SREBP-1c promoter by pharmacological PPAR activators. pLXRE-Luc was co-transfected into HEK293 cells with pCMV-LXRalpha or an empty vector, CMV-7 as a control and pSV-etagal as a reference plasmid ( A ). pPPRE-Luc was co-transfected into HEK293 cells with pCMV-PPARalpha, pCMV-PPARgamma, or an empty vector, CMV-7 as a control, and pSV-etagal as a reference plasmid ( B ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| Organ | liver |
| MedLine Reference | 12730331:1055 |
| Sentence | Even without LXR activation, overexpression of PPAR substantially decreased the basal activity of the SREBP-1c promoter. |