| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:4792::positive |
| Entities | PPARA --+> NFKBIA |
| References | 5 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i47 p36703 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/47/36703 |
| Organ | aorta |
| MedLine Reference | 10980195:1075 |
| Sentence | Next, it was investigated whether PPARalpha agonists influence IkappaBalpha expression. |
| Tissue | smooth muscle |
|---|---|
| Organ | aorta |
| MedLine Reference | 11981037:3 |
| Sentence | Here, we studied the molecular mechanisms by which PPARalpha controls IkappaBalpha expression. |
| Organism | Mus musculus |
|---|---|
| CellLineName | HuH7 |
| CellType | hepatocyte |
| MedLine Reference | 12393563:10 |
| Sentence | First, PPAR-alpha increases IkappaB-alpha expression and thus prevents p50-NFkappaB translocation to the nucleus. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i41 p39874 (2003) |
| Tissue | microvascular |
| Journal Link | http://www.jbc.org/cgi/content/full/278/41/39874 |
| MedLine Reference | 12878589:1145 |
| Sentence | Mechanisms involved reportedly include direct PPARalpha interaction with p65 and PPARalpha-dependent expression of IkappaBalpha, sequestering the inactive p65/p50 complex in the cytoplasm ( 24 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Blood |
| Journal Reference | v103 i11 p4188 (2004) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/103/11/4188 |
| Organ | liver |
| MedLine Reference | 14976045:1021 |
| Sentence | A molecular rationale for the suppression of IL-1-induced huCRP transcription is provided by showing that statins and PPARalpha activators up-regulate IkappaBalpha protein expression. |