| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:3725::negative |
| Entities | JUN |--- PPARA |
| References | 3 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i45 p32048 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/45/32048 |
| MedLine Reference | 10542237:1161 |
| Sentence | By contrast, the truncated form of PPARalpha was able to repress c-Jun transactivation to a similar extent as the wild-type PPARalpha (-60%) (Fig. 6 D ). |
| Journal | Circulation Res |
|---|---|
| Journal Reference | v85 i5 p394 (1999) |
| Tissue | endothelial |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/85/5/394 |
| Organ | aorta |
| MedLine Reference | 10473669:1014 |
| Sentence | Furthermore, electrophoretic mobility shift assays demonstrated that PPAR activators reduce the thrombin-stimulated binding activity of bovine aortic endothelial cell nuclear extracts as well as c-Jun binding to an activator protein-1 consensus site. |
| Journal | Mol. Endocrin |
|---|---|
| CellType | hepatocyte |
| Journal Reference | v16 i5 p1013 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/5/1013 |
| MedLine Reference | 11981036:1022 |
| Sentence | In addition, PPAR represses gene transcription by interfering with the nuclear factor B (NF B) and activating protein 1 (AP1) signaling pathways in a DNA binding-independent fashion ( 2 ). |