| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:116519::positive |
| Entities | APOA5 <+-- PPARA |
| References | 5 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i20 p17982 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/20/17982 |
| MedLine Reference | 12637506:1066 |
| Sentence | Cotransfection with PPARalpha strongly stimulated the APOA5 promoter activity (about a 25-fold increase with construct -846/+62 and about a 40-fold increase with construct 305/+62) in the presence of Wy 14,643 (Fig. 3 ). |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i28 p25468 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/28/25468 |
| MedLine Reference | 12709436:1000 |
| Sentence | " " The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-alpha and Contains a Novel Farnesoid X-activated Receptor Response Element -- Prieur et al. 278 (28): 25468 -- Journal of Biological Chemistry -1) { var tempwn = windowname.substring(0,dotpos) + windowname.substring(dotpos + 1, windowname.length); windowname = tempwn; } var sizestring = 'width=' + wid + ',height=' + hei; window.open('',windowname,'scrollbars,resizable,' + sizestring + '\''); } // -- |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p45462 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/45462 |
| Organ | liver |
| MedLine Reference | 15317819:1032 |
| Sentence | It has been reported that the APOA5 gene is regulated by peroxisome proliferator-activated receptor-alpha and farnesoid X receptor ligands, both nuclear receptors implicated in triglyceride metabolism ( 9 , 10 ). |
| Organism | Mus musculus |
|---|---|
| Journal | JPET |
| Journal Reference | v309 i3 p861 (2004) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| MedLine Reference | 14960661:1235 |
| Sentence | It was also reported recently that activation of PPARalpha increased the expression of apoAV, the newly identified secreted protein that plays a critical role in determining plasma triglyceride levels in humans (Vu-Dac et al., 2003 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v25 i4 p1537 (2005) |
| Journal Link | http://mcb.asm.org/cgi/content/full/25/4/1537 |
| Organ | liver |
| MedLine Reference | 15684402:1030 |
| Sentence | Finally, peroxisome proliferator-activated receptor alpha (PPARalpha) agonists are known to have hypotriglyceridemic effect, and several recent studies demonstrated that the APOA5 gene is highly up-regulated by PPARalpha and the farnesoid X receptor ( 44 , 61 ). |