| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:3172:out-urn:agi-llid:5465::positive |
| Entities | HNF4A --+> PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | COS |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v16 i5 p1013 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/5/1013 |
| MedLine Reference | 11981036:1013 |
| Sentence | Transient transfections in HepG2 and Cos cells showed that HNF4 enhances hPPAR promoter activity. 5'-Deletion and mutation analysis of the hPPAR promoter identified a regulatory element (RE) consisting of a degenerate hexamer repeat with a single nucleotide spacer (direct repeat 1), termed HNF4-RE. |
| Journal | Mol. Endocrin |
|---|---|
| CellType | hepatocyte |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| Organ | liver |
| MedLine Reference | 15087471:1139 |
| Sentence | It has been proposed that HNF4alpha up-regulates PPAR alpha gene expression ( 54 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i16 p14011 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/16/14011 |
| MedLine Reference | 11834723:1177 |
| Sentence | Moreover, our microarray data showed that PPARalpha was induced by HNF-4alpha. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v41 i3 p514 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/3/514 |
| MedLine Reference | 10744771:1069 |
| Sentence | PPAR , RXR , and HNF-4 were synthesized in vitro by programming transcription/translation (TNT) system (Promega) with the expression vectors pcDNA3-hPPAR , pCMX-RXR , and pCMV-HNF4, respectively. |