| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- PPARA |
| References | 5 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i2 p1486 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/2/1486 |
| Organ | liver |
| MedLine Reference | 11050084:1258 |
| Sentence | However, since they have been studied in tissues such as liver, which highly expresses PPARalpha but not PPARgamma, or WAT , which predominantly expresses PPARgamma, tissue-specific regulation has been suggested. |
| Journal | Cell |
|---|---|
| Journal Reference | v87 i3 p377 (1996) |
| Journal Link | http://www.cell.com/cgi/content/full/87/3/377 |
| MedLine Reference | 2589919970 |
| Sentence | In fact, the anti-diabetic TZDs BRL49653 and pioglitazone elicit a strong activation of PPARgamma, with relatively little activity on PPARalpha and delta ( Lehmann et al., 1995 ; Forman et al., 1995 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 10873645:5 |
| Sentence | Thus, activation of PPARgamma increases UCP-1 and UCP-3 levels which are differentially regulated by PPARalpha. |
| MedLine Reference | 11779144:2 |
|---|---|
| Sentence | We found that bezafibrate was a ligand for PPARalpha, delta, and gamma in the CARLA and that bezafibrate induced transcriptional activation of PPARalpha/RXRalpha, PPARdelta/RXRalpha, and PPARgamma/RXRalpha. |
| MedLine Reference | 10962863:2 |
|---|---|
| Sentence | PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPAR gamma) and catabolic (PPAR alpha) pathways of lipid metabolism. |