| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:284541::positive |
| Entities | similar to cytochrome P450, 4a12 <+-- PPARA |
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | JPET |
| Journal Reference | v299 i2 p691 (2001) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/299/2/691 |
| Organ | renal |
| MedLine Reference | 11602682:1203 |
| Sentence | Consistent with previous reports of an induction of CYP4A1 transcription by PPARalpha activators (Chen and Hardwick, 1993 ), WY-14,643 treatment increased levels of CYP4A1 mRNA. |
| Organism | Rattus norvegicus |
|---|---|
| CellType | hepatocyte |
| MedLine Reference | 9354589:5 |
| Sentence | As it has been shown that the peroxisome proliferator-activated receptor alpha (PPAR alpha) mediates the induction of the CYP4A1 gene by a peroxisome proliferator, the capacity of IL-1beta or IL-6 to modulate the PPAR alpha mRNA level was tested. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i36 p28285 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28285 |
| Organ | liver |
| MedLine Reference | 10866995:1108 |
| Sentence | In contrast to the AOX , MCAD , and malic enzyme genes, the basal transcription of the CYP4A1 and LFABP genes can be controlled by PPARalpha/RXRalpha at the physiological level. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i27 p19228 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/27/19228 |
| Organ | liver |
| MedLine Reference | 10383430:1225 |
| Sentence | The functional PPARalpha leads to the transcriptional activation of CYP4A1 and CYP4A3 genes in AOX -/- mouse liver by natural PPARalpha ligands, such as VLCFAs or their acyl-CoA esters that remain unmetabolized in the absence of AOX ( 16 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i22 p15775 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/22/15775 |
| Organ | liver |
| MedLine Reference | 10336479:1142 |
| Sentence | Acyl-CoA synthetase ( ACS ), AOX , L -PBE, PTL , CYP4A1, CYP4A3, D -PBE, and fatty acid-binding protein ( FABP ) genes are transcriptionally activated by PPARalpha. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i11 p9562 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/11/9562 |
| Organ | heart |
| MedLine Reference | 11782473:1035 |
| Sentence | PPARalpha activators increase in the expression of H 2 O 2 -generating peroxisomal fatty acyl-CoA oxidase and microsomal cytochrome P450 4A1 and 4A3 genes. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 9707502:1 |
| Sentence | The involvement of PPAR in the peroxisome proliferator-mediated induction of fatty acid metabolizing genes such as acyl-CoA oxidase (ACO), fatty acid-binding protein (FABP), and cytochrome P450IVA1 (CYP4A1) has been clearly demonstrated. |