| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:5319::positive |
| Entities | PLA2G1B <+-- PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | HepG 2 |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v282 i4 pG586 (2002) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/282/4/G586 |
| MedLine Reference | 11897617:1256 |
| Sentence | PPAR-alpha activity in cells with altered PLA2 expression. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i19 p16015 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/19/16015 |
| Organ | colon |
| MedLine Reference | 11279149:1255 |
| Sentence | However, PPARalpha activation by oxidized phospholipids depends on phospholipase A 2 activity ( 13 ), suggesting that the oxidized free fatty acid products of this reaction are the actual ligands for PPARalpha. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i41 p39874 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/41/39874 |
| MedLine Reference | 12878589:1274 |
| Sentence | The effects of oxLDL on PPARalpha may depend on cytoplasmic phospholipase A2 action ( 30 ); this is not likely relevant to the results presented here, because LPL neither acts on nor binds to oxLDL ( 16 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | H9c2 |
| Journal | Lipid Res |
| Journal Reference | v45 i2 p244 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/244 |
| MedLine Reference | 14594999:1235 |
| Sentence | To further confirm this and to confirm that PLA2 and PGP synthase activities are indeed regulated by PPARalpha activation, the activities of these enzymes were examined in PPARalpha-null mice treated with clofibrate. |