| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:4843::unknown |
| Entities | PPARA ---> NOS2A |
| References | 9 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| CellType | hepatocyte |
| Journal Reference | v286 i4 pG606 (2004) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/286/4/G606 |
| Organ | liver |
| MedLine Reference | 14615282:1188 |
| Sentence | One alternative mechanism that we examined was the possibility that PPARalpha may regulate the expression of iNOS and therefore alter the production of NO. iNOS has been shown to localize within the peroxisomal membranes in hepatocytes ( 30 ), and our data demonstrate that hepatic ischemia-reperfusion induces peroxisomal proliferation, an effect that is reduced in PPARalpha-/- mice. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Hypertension |
| Journal Reference | v35 i6 p1232 (2000) |
| Tissue | smooth muscle |
| Journal Link | http://hyper.ahajournals.org/cgi/content/full/35/6/1232 |
| MedLine Reference | 10856269:1058 |
| Sentence | Effects of PPAR Agonists on iNOS mRNA and Protein Levels We then examined whether PPAR agonists decreased iNOS mRNA accumulation in vascular smooth muscle cells. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i36 p33518 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/36/33518 |
| MedLine Reference | 12093797:1022 |
| Sentence | Concomitantly, activators of PPARalpha potentiated the cytokine-induced iNOS expression. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Immunol |
| CellType | macrophage |
| Journal Reference | v169 i5 p2619 (2002) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/169/5/2619 |
| MedLine Reference | 12193733:1227 |
| Sentence | NO-mediated inhibition of superoxide radical production is due to PPAR -dependent down-regulation of p47phox Modulation of gene expression in response to PPAR activation is known and associated with, e.g., inhibition of iNOS expression ( 13 ). |
| Journal | J. Neurochem |
|---|---|
| Tissue | microglia |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2002.00990.x/full/ |
| MedLine Reference | 3436867721 |
| Sentence | The inhibition of iNOS by pioglitazone is consistent with the ability of PPAR to interact with coactivators to repress iNOS promoter activity in response to ligand binding ( Li et al . 2000 ). |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 11890746:1 |
| Sentence | PPAR activation in nonadipose tissues seems to inhibit iNOS and COX2 expression. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | astrocyte |
| Journal Reference | v277 i48 p45984 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/48/45984 |
| MedLine Reference | 12244038:1034 |
| Sentence | Recently it has been shown that activation of HSP70 inhibits the expression of iNOS in astrocytes ( 15 ), suggesting that the expression of iNOS may also be regulated by activators of PPAR-alpha. |
| CellType | macrophage |
|---|---|
| Tissue | smooth muscle |
| MedLine Reference | 2943073829 |
| Sentence | It has been demonstrated that PPAR-alpha inhibits inducible NOS (NOS II) in macrophages and prevents the expression of cyclooxygenase-2 (COX-2) (Staels et al., 1998 ) in smooth muscle cells. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Neurosci |
| CellType | macrophage |
| Journal Reference | v21 i17 p6522 (2001) |
| Tissue | microglia |
| Journal Link | http://www.jneurosci.org/cgi/content/full/21/17/6522 |
| MedLine Reference | 11517241:1011 |
| Sentence | The activation of PPAR reduces the expression of proinflammatory cytokines and the inducible form of nitric oxide synthase (iNOS) in macrophages ( Lemberger et al . 1996 ; Ricote et al . 1998b ), monocytes ( Jiang et al . 1998 ), microglial cells ( Bernardo et al . 2000 ), and neurons ( Heneka et al . 2000 ), suggesting a role of PPAR in inflammatory events. |