| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:7350::positive |
| Entities | PPARA --+> UCP1 |
| References | 8 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v139 i12 p4920 (1998) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/12/4920 |
| MedLine Reference | 9832429:1221 |
| Sentence | Having demonstrated that in vivo activation of PPARgamma by potent and selective TZDs can modulate the expression of UCP isoforms in BAT and BAT morphology, we sought to also test whether in vivo treatment with a PPARalpha agonist might affect UCP gene expression. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | PAZ6 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i19 p16750 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/19/16750 |
| MedLine Reference | 11875072:1181 |
| Sentence | The putative PGC-1 repressor specifically interfered with PPARalpha-mediated up-regulation of the UCP1 gene. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i24 p21489 (2002) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/277/24/21489 |
| MedLine Reference | 11940593:1246 |
| Sentence | For instance, the UCP1 gene, expression of which is most affected by the absence of C/EBPalpha, is also regulated by PPAR , T 3 R , and coactivator PGC-1 , whose expression is also altered. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i2 p1486 (2001) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/276/2/1486 |
| MedLine Reference | 11050084:1009 |
| Sentence | All Versions of this Article: 276/2/1486 (most recent) M006246200v1 Peroxisome Proliferator-activated Receptor alpha Activates Transcription of the Brown Fat Uncoupling Protein-1 Gene |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v42 i3 p372 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/3/372 |
| Organ | liver |
| MedLine Reference | 11254749:1146 |
| Sentence | Many genes related to lipid metabolism such as ACO and UCP are known to be regulated by PPAR in the liver ( 28 ) ( 29 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 (2002) |
| Tissue | fat |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| Organ | heart |
| MedLine Reference | 12032169:1229 |
| Sentence | PPAR also induces UCP1 expression in brown fat ( 24 ) and UCP3 expression in the heart ( 19 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 10873645:5 |
| Sentence | Thus, activation of PPARgamma increases UCP-1 and UCP-3 levels which are differentially regulated by PPARalpha. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v16 i6 p1185 (2002) |
| Tissue | mammary gland |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1185 |
| MedLine Reference | 12040007:1251 |
| Sentence | Given that PGC-1 has been shown to act as a transcriptional coactivator for PPAR ( 52 , 48 ), and that high levels of PPAR mRNA are found in the 2-wk-old mammary gland, it is possible that basal levels of PGC-1 and PPAR expression are sufficient for high levels of expression of Ucp1 in the mammary glands of neonatal mice housed at room temperature. |