| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:336::positive |
| Entities | APOA2 <+-- PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| CellLineName | JEG3 |
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2571 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2571 |
| MedLine Reference | 12072389:1397 |
| Sentence | Decreases in circulating cholesterol and triglyceride levels after fibrate therapy ( 64 ) were attributed to increases in apolipoprotein A-II levels mediated by PPARalpha ( 69 ); and clofibrate was found to alter cell growth and gene expression and to inhibit progesterone synthesis in human choriocarcinoma JEG-3 cells ( 28 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v272 i43 p27307 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/43/27307 |
| Organ | liver |
| MedLine Reference | 9341179:1148 |
| Sentence | Human liver apoA-II expression is stimulated by PPARalpha. |
| CellLineName | HepG 2 |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v282 i4 pG586 (2002) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/282/4/G586 |
| MedLine Reference | 11897617:1362 |
| Sentence | Furthermore, experiments with overexpression of cPLA2 and group IIA sPLA2 and antisense inhibition of cPLA2 have also demonstrated an important role of cPLA2 but not group IIA sPLA2 in the expression of the endogenous PPAR-mediated gene apolipoprotein A-II (Fig. 11 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i7 p4634 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/7/4634 |
| Organ | liver |
| MedLine Reference | 11050100:1177 |
| Sentence | In this respect, apolipoprotein A-II is another major protein of HDL ( 56 ) whose expression is transcriptionally induced by activation of PPARalpha in mice and humans ( 25 , 32 , 57 ). |