| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:5166::positive |
| Entities | PDK4 <+-- PPARA |
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v284 i5 pE855 (2003) |
| Tissue | fat |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/5/E855 |
| MedLine Reference | 12676647:1170 |
| Sentence | Because of the clear correlation between altered lipid homeostasis and tissue PDK4 protein expression and the resulting impact that this might have on rates of glucose oxidation, much current interest has been focused on the potential regulation of PDK4 expression by PPARalpha. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v287 i1 pE69 (2004) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/287/1/E69 |
| MedLine Reference | 15026305:1161 |
| Sentence | PPARalpha has been suggested to play a major role in the regulation of PDK-4 expression with starvation or diabetes. |
| Organism | Mus musculus |
|---|---|
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH270 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H270 |
| Organ | heart |
| MedLine Reference | 12663261:1118 |
| Sentence | Therefore, contrary to our expectations, protein expression of PDK4 was only marginally influenced by PPAR-alpha overexpression. |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11554740:3 |
| Sentence | Free fatty acids can activate peroxisome proliferator-activated receptor alpha (PPARalpha), and activation of PPARalpha can promote PDK4 expression. |
| Organism | Mus musculus |
|---|---|
| Tissue | tubule |
| Organ | renal |
| MedLine Reference | 14612380:6 |
| Sentence | Cisplatin also induced increased mRNA and protein levels of pyruvate dehydrogenase kinase-4 (PDK4), and PPAR alpha ligand WY prevented cisplatin-induced increased expression of PDK4 protein levels in wild-type mice. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | muscle |
| Organ | heart |
| MedLine Reference | 15292029:6 |
| Sentence | Specific activation of PPAR alpha with WY-14643 rapidly induced pdk4 expression in heart and soleus muscle. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2477 (2003) |
| Tissue | muscle |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2477 |
| MedLine Reference | 14525954:1188 |
| Sentence | Interestingly, PDK4 mRNA was activated by PPARalpha, -A?/delta, and -gamma agonists. |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| Organ | liver |
| MedLine Reference | 15087471:1149 |
| Sentence | PPARalpha exerts a direct role in the regulation of gluconeogenesis via stimulation of the expression of pyruvate dehydrogenase kinase 4 (PDK4) ( 57 ). |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | islet |
| MedLine Reference | 11723055:8 |
| Sentence | Thus, although no changes in islet PPAR-alpha expression were observed after the starvation protocol, activation of PPAR-alpha in vivo may be a potential mechanism underlying upregulation of islet PDK4 protein expression in starvation. |
| Organ | liver |
|---|---|
| MedLine Reference | 12798359:6 |
| Sentence | Thus, induction of PDK-4 by PPARalpha agonists in the HK-2 cell model closely correlates with its induction in vivo and may represent an early marker for PPARalpha agonist action. |