| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:345::negative |
| Entities | APOC3 |--- PPARA |
| References | 13 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v284 i4 pE841 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/4/E841 |
| Organ | liver |
| MedLine Reference | 12475752:1258 |
| Sentence | Similarly, as for fibrates and other PPARalpha agonists that have been reported to reduce the liver expression of ApoCIII, a major component of VLDL particles, it was observed that ragaglitazar but not rosiglitazone elicited this change. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | hepatocyte |
| Journal Reference | v276 i34 p31521 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/34/31521 |
| MedLine Reference | 11418601:1160 |
| Sentence | In addition, PPARalpha agonist treatment suppressed apo CIII mRNA at the same doses that induced FACO activity. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i30 p27120 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/30/27120 |
| Organ | liver |
| MedLine Reference | 12021280:1230 |
| Sentence | Studies with PPARalpha knockout mice have clearly demonstrated that PPARalpha is required in the negative regulation of apoCIII gene expression by fibrates ( 64 ). |
| Organism | Mus musculus |
|---|---|
| Journal | JPET |
| Journal Reference | v309 i3 p861 (2004) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| MedLine Reference | 14960661:1234 |
| Sentence | PPARalpha activation has been shown to reduce apoCIII levels in humans, thus increasing LPL activity and triglyceride hydrolysis (Staels et al., 1995 ). |
| Tissue | skeletal muscle |
|---|---|
| Organ | heart |
| MedLine Reference | 10431661:5 |
| Sentence | The effect of fibrates on the metabolism of triglyceride-rich lipoproteins is due to a PPAR-alpha dependent stimulation of lipoprotein lipase and an inhibition of apolipoprotein C-III expressions, whereas the increase in plasma HDL cholesterol depends on an overexpression of apolipoprotein A-I and apolipoprotein A-II. |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v18 i6 p1321 (2004) |
| Tissue | vascular |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| MedLine Reference | 15087471:1123 |
| Sentence | Both PPARalpha and PPARgamma modulate the lipoprotein serum profile via increased expression of lipoprotein lipase (LPL) (reviewed in Ref. 48 ) and decreased expression of apolipoprotein (apo)CIII, an inhibitor of LPL activity. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i44 p41293 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/44/41293 |
| Organ | liver |
| MedLine Reference | 11546766:1219 |
| Sentence | PPARalpha activation by fibrates lowers plasma triglyceride ( 28 ) and represses apoCIII ( 28 ) and Aalpha-fibrinogen expression ( 49 ). |
| Tissue | fat |
|---|---|
| MedLine Reference | 9361824:9 |
| Sentence | PPAR directly activates genes like AOX, but also inhibits transcription of genes like S14, FAS, apolipoprotein CIII, transferrin. |
| Organ | liver |
|---|---|
| MedLine Reference | 10774955:6 |
| Sentence | Upon fibrate activation, PPARalpha down-regulates hepatic apolipoprotein C-III and increases lipoprotein lipase gene expression, key players in triglyceride metabolism. |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| MedLine Reference | 12746275:1054 |
| Sentence | PPARalpha has also been shown to down-regulate apolipoprotein C-III, a protein which inhibits TG hydrolysis by LPL. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | hepatocyte |
| Journal Reference | v278 i20 p17982 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/20/17982 |
| MedLine Reference | 12637506:1119 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Mol. Pharm |
| CellType | hepatocyte |
| Journal Reference | v54 i3 p463 (1998) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/54/3/463 |
| Organ | liver |
| MedLine Reference | 9730905:1317 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v273 i10 p5678 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/10/5678 |
| MedLine Reference | 9488698:1169 |