| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-enz:2.3.1.21::unknown |
| Entities | carnitine O palmitoyltransferase <--- PPARA |
| References | 8 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 15489052:4 |
| Sentence | Although PPARalpha expression and binding activity was reduced in liver from old male and female rats, the mRNA for a PPARalpha target gene, such as CPT-I, was reduced in old males (-56%), while increased by 286% in old females. |
| Journal | Mol. Endocrin |
|---|---|
| CellType | hepatocyte |
| Journal Reference | v18 i8 p1906 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/8/1906 |
| MedLine Reference | 15131257:1057 |
| Sentence | As a consequence, the induction of PPARalpha target genes, such as CPT-I and PPARalpha itself, is abolished. |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v280 i2 pE270 (2001) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/280/2/E270 |
| Organ | liver |
| MedLine Reference | 11158930:1183 |
| Sentence | In addition to effects on hepatic apolipoprotein expression, we show here that PPARalpha agonist treatment influences CPT I expression. |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v286 i2 pE168 (2004) |
| Tissue | skeletal muscle |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/2/E168 |
| Organ | liver |
| MedLine Reference | 14519597:1162 |
| Sentence | The underlying mechanisms may be explained by 1 ) activation of PPARalpha, redirecting fatty acids from peripheral tissues (e.g., skeletal muscle) to the liver, because hepatic PPARalpha CPT-I and CD36 expression is increased ( 13 ) by PPARalpha agonist administration; and/or 2 ) increased glucose utilization in adipose tissue because GLUT4 mRNA levels are increased in visceral adipose tissue by lipid infusion ( 7 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v273 i15 p8560 (1998) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/273/15/8560 |
| Organ | heart |
| MedLine Reference | 9535828:1025 |
| Sentence | In CV1 cells, the activation of the CPT I gene by PPAR was dependent on the addition of exogenous ligands. |
| Organism | Mus musculus |
|---|---|
| CellLineName | HepG 2 |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i2 p259 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/2/259 |
| MedLine Reference | 12554753:1156 |
| Sentence | Since basal expression levels of CPT-I are regulated by PPAR in the absence of added PPAR ligand ( 50 ), up-regulation of CPT-I gene expression may be due, at least in part, to the increased PPAR expression after BA treatment. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| CellType | cardiomyocyte |
| Journal Reference | v41 i1 p41 (2000) |
| Tissue | muscle |
| Journal Link | http://www.jlr.org/cgi/content/full/41/1/41 |
| MedLine Reference | 10627500:1173 |
| Sentence | Just recently it was demonstrated that the expression of muscle-type CPTI is also PPAR -dependent ( 32 ) and that exposure of neonatal cardiomyocytes to long-chain fatty acids activates transcription of the CPTI promoter via a PPRE ( 7 ). |
| Journal | Reg.Int.Comp.Phys |
|---|---|
| CellType | myocyte |
| Journal Reference | v281 i5 pR1553 (2001) |
| Tissue | muscle |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/281/5/R1553 |
| Organ | heart |
| MedLine Reference | 11641128:1181 |
| Sentence | The gene for muscle-type CPT-I in cardiac myocytes was shown to contain a PPRE that was activated by PPAR-alpha ( 8 ). |