| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:7352::positive |
| Entities | UCP3 <+-- PPARA |
| References | 16 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v278 i1 p263 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/1/263 |
| MedLine Reference | 12414803:1016 |
| Sentence | PPARalpha and gamma agonists but not retinoids also increase UCP-3 expression in fetal brown adipocytes. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 (2002) |
| Tissue | fat |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| Organ | heart |
| MedLine Reference | 12032169:1229 |
| Sentence | PPAR also induces UCP1 expression in brown fat ( 24 ) and UCP3 expression in the heart ( 19 ). |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i10 p1944 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/10/1944 |
| MedLine Reference | 12843208:1053 |
| Sentence | Bezafibrate, which activates both PPARalpha and PPARdelta, induced the UCP3 promoter when either of the two receptors was cotransfected. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | muscle |
| Organ | heart |
| MedLine Reference | 15292029:8 |
| Sentence | The same pattern of induction was observed for the PPAR alpha-regulated genes malonyl-CoA decarboxylase and uncoupling protein 3. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 15292030:2 |
| Sentence | We previously showed that ucp3 is a peroxisome proliferator-activated receptor-alpha (PPAR alpha)-regulated gene, allowing induction when FA availability increases. |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v277 i5 pE830 (1999) |
| Tissue | muscle |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/277/5/E830 |
| MedLine Reference | 10567009:1196 |
| Sentence | Recently, PPAR-alpha has been implicated in the regulation of UCP-3 gene expression in neonatal muscle in mice ( 10 ). |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v286 i2 pE168 (2004) |
| Tissue | skeletal muscle |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/2/E168 |
| MedLine Reference | 14519597:1186 |
| Sentence | PPARalpha agonists upregulate expression of UCP-3 in rat skeletal muscle ( 4 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | L6 |
| Journal | Endocrinology |
| CellType | myotube |
| Journal Reference | v142 i10 p4189 (2001) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/10/4189 |
| MedLine Reference | 11564673:1126 |
| Sentence | Regulation of UCP3 gene expression by specific PPAR agonists We investigated the regulation of UCP3 gene expression by specific PPAR agonists in L6 myotubes. |
| Organism | Mus musculus |
|---|---|
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH1 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H1 |
| Organ | heart |
| MedLine Reference | 12623780:1409 |
| Sentence | Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. |
| Organism | Mus musculus |
|---|---|
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH270 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H270 |
| Organ | heart |
| MedLine Reference | 12663261:1281 |
| Sentence | Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i29 p26089 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/29/26089 |
| Organ | heart |
| MedLine Reference | 12118038:1213 |
| Organism | Rattus norvegicus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 10873645:5 |
| Organism | Mus musculus |
|---|---|
| Tissue | muscle |
| MedLine Reference | 10342807:9 |
| Organism | Mus musculus |
|---|---|
| Organ | heart |
| MedLine Reference | 11259402:9 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i2 p388 (2003) |
| Tissue | muscle |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/388 |
| MedLine Reference | 12576521:1129 |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | MSL |
| Journal | EBM |
| Journal Reference | v224 i3 p172 (2000) |
| Tissue | muscle |
| Journal Link | http://www.ebmonline.org/cgi/content/full/224/3/172 |
| Organ | heart |
| MedLine Reference | 10865233:1110 |